Audrey DEYAWE

En résumé

Entreprises

• CNRS - PhD student in Theoretical Chemistry

  Paris 2015 - maintenant Modulation of the function of voltage-gated ion channels: MD simulations studies

• CNRS - Research intern at the Centre de Biochimie Structurale

  Paris 2015 - 2015 Evaluation of the ability of EDMon (http://atome2.cbs.cnrs.fr/AT2B/SERVER/EDMon.html) in predicting the activity of endocrine disruptors on nuclear receptors.
  EDMon is a molecular docking tool based upon the structural homology of crystallographic complexes. It uses crystallographic structures of 18 nuclear receptors of two species (Human, Zebrafish) which are known to be able to interact with endocrine disruptors, and associated to numerous developmental and reproduction diseases such as cancer, obestity and diabetes.
  Atotal number of 101 endocrine disruptors (bisphenols, alkylphenols, flame retardants, phtalates, parabens, phytoestrogens/mycoestrogens) were docked (using EDMon) in positions very close to the crystallographic ones on estrogen receptors ER alpha and ER bêta. (percentages of correct positions according to the interaction fingerprints (IFP) of the template structures extracted from PDB: ERalpha: 0.84 ERbêta: 0.88) For a small sample of 37 ligands, the activity score values obtained with EDMon were significantly correlated ( Pearson coefficients: ER alpha: 0.55, ER bêta: 0.47) to EC50 values measured via in vitro methods on both receptors.
  Several ligands, including pesticides such as vinclozolin (CAS:50471-44-8) and its metabolite vinclozolin M2 (CAS:83792-61-4) were selected for further crystallographic tests with human ER alpha receptors. If crystallographic data can be obtained for these compounds, their structures will be included in EDMon template structures in order to enhance the predictive ability of EDMon for pesticide ligands.
  
  
  

• Inserm - Intern at Laboratoire des Molécules Thérapeutiques In silico (MTi)

  PARIS 13 2014 - 2014 Research unit: UMR-S 973
  QSAR analysis of 500 crystallographic protein-ligand complexes defined by 24 physico-chemical descriptors
  
  
  

• ACADOMIA - Mathematics/Physics/Chemistry Tutor

  Paris 2013 - 2014 Mathematics: tutoring from 8th grade (in France: 4ème) to 10th grade (in France: seconde) levels.
  Physics/Chemistry: classroom sessions from 10th grade to 12th grade (in France: terminale)

• Pénélope - Hostess

  Paris 2011 - 2015 On vacation replacement of the employees, the sick leave or the occupational accident.
  Intervention with numerous companies: Rodin museum, notary's offices, property developers, financial offices...

• City One - Hostess

  Paris 2009 - 2011 Management of different reception spots of the museum:
  -ticketing
  -information spot
  -visioguide service (small devices with a tactile screen designed to help visitors during the discovery of the museum)
  -cloakroom
  -ticket control

Formations

• Université De Lorraine

  Nancy 2015 - maintenant PhD student in Theoretical Chemistry
  
  Modulation of the function of voltage-gated ion channels: MD simulations studies

• Université Paris VII Denis Diderot

  Paris 2014 - 2015 Master 2 In Silico Drug Design (third semester)
  
  Data mining (Statistics and data analysis), Virtual Screening (ligand based, structure based), Molecular modelling (molecular dynamics, homology modelling), Toxicology

• Università Degli Studi Di MILANO CTF (Milano)

  Milano 2013 - 2013 Master 1 In Silico Drug Design (second semester)
  
  ERASMUS semester with english speaking lectures
  Theoretical Molecular modelling, Medicinal Chemistry, Structural Biology, Enzymology, Rational Design of bioactive molecules, C Programming, Italian language

• Université De Strasbourg (UdS)

  Strasbourg 2012 - 2012 Master 1 In Silico Drug Design (first semester)
  
  Cheminformatics, Organic Chemistry, Statistics, Molecular modelling

• Université Paris V - René Descartes

  Paris 2009 - 2012 Sciences Biomédicales
  
  Chimie Organique et Bioorganique, Chimie Verte, Chimie des substances naturelles
  Biochimie, Biologie Moléculaire, Génétique
  Adhérente a l'association Amicale Paris Sciences (APS), Rédaction de cours magistraux (ronéos) de chimie organique pour les autres adhérents

• Université Paris V Descartes

  Paris 2007 - 2009 PCEP1
  
  First year of pharmaceutical studies

• Lycée Van Gogh

  Ermont 2004 - 2007 Scientific Baccalaureate

Réseau

• Amel BOUZIANE

• Fati SERIDJ

• Jean Baptiste POUYAU

• Joan CLARK NICOLAS

• Maud CHEVALIER

• Meriem CHIMISTE