Frédéric FINA

Demande d'accrédiation 15189 portée B flexible pour l'extraction d'ADN et la mise en évidence des mutations de l'EGFR-KRAS et BRAF après criblage HRM des mutations et séquençage des profils anormaux dans le cadre du traitement, respectivement, des cancers bronchiques non à petites cellules et des mélanomes métastatiques par thérapies ciblées .
Automatisation de la chaîne analytique
Veille technologique, test du matériel à venir

Travaux de recherche clinique:
Ciccolini, J., et al., Pharmacogenetics and Pharmacogenomics of Colorectal Cancer: Moving Towards Personalized Medicine. Rajunor Ettarh ed. Colorectal Cancer - From Prevention to Patient Care. 2012: InTech.
Quillien, V., et al., Comparative assessment of 5 methods (methylation-specific polymerase chain reaction, methylight, pyrosequencing, methylation-sensitive high-resolution melting, and immunohistochemistry) to analyze O6-methylguanine-DNA-methyltranferase in a series of 100 glioblastoma patients. Cancer, 2012.
Jacot, W., et al., Lack of EGFR activating mutations in European patients with triple negative breast cancer could emphasize geographic and ethnic variations in breast cancer mutation profiles. Breast Cancer Res, 2012. 13(6): p. R133.
Metellus, P., et al., Prognostic Impact of CD133 mRNA Expression in 48 Glioblastoma Patients Treated with Concomitant Radiochemotherapy: A Prospective Patient Cohort at a Single Institution. Ann Surg Oncol, 2011.
Metellus, P., et al., Adrenomedullin expression and regulation in human glioblastoma, cultured human glioblastoma cell lines and pilocytic astrocytoma. Eur J Cancer, 2011.
Lamy, P.J., et al., Quantification and clinical relevance of gene amplification at chromosome 17q12-q21 in human epidermal growth factor receptor 2-amplified breast cancers. Breast Cancer Res, 2011. 13(1): p. R15.
Fina, F., et al., Epstein-Barr virus as a marker of biological aggressiveness in breast cancer. Br J Cancer, 2011. 104(2): p. 332-7.
Fina, F., C. Mazouni, and P.M. Martin, Reply: Is Epstein-Barr virus associated with aggressive forms of breast cancer? Br J Cancer, 2011.
Coulibaly, B., et al., Epidermal growth factor receptor in glioblastomas: correlation between gene copy number and protein expression. Hum Pathol, 2010.
Bennani, B., et al., Mutation analysis of BRAF exon 15 and KRAS codons 12 and 13 in Moroccan patients with colorectal cancer. Int J Biol Markers, 2010. 25(4).
Tchoghandjian, A., et al., Pilocytic astrocytoma of the optic pathway: a tumour deriving from radial glia cells with a specific gene signature. Brain, 2009. 132(Pt 6): p. 1523-35.
Metellus, P., et al., Prognostic impact of O6-methylguanine-DNA methyltransferase silencing in patients with recurrent glioblastoma multiforme who undergo surgery and carmustine wafer implantation: a prospective patient cohort. Cancer, 2009. 115(20): p. 4783-94.
Fina, F., et al., [Strategy for studying gene methylation: the example of MGMT]. Ann Pathol, 2009. 29 Spec No 1: p. S37-9.
Deville, J.L., et al., Expression and role of adrenomedullin in renal tumors and value of its mRNA levels as prognostic factor in clear-cell renal carcinoma. Int J Cancer, 2009.
Colin, C., et al., High expression of cathepsin B and plasminogen activator inhibitor type-1 are strong predictors of survival in glioblastomas. Acta Neuropathol, 2009.
Barlesi, F., et al., Non-small cell lung cancer-smokers or non-smokers, does it matter? Lung Cancer, 2009. 63(3): p. 430-2.