University of California at Santa Barbara, UCSB
- Post-Doctoral Research Scientist under the supervision of Pr A. Zakarian
2008 - 2010
Development of a new ruthenium catalyzed radical haloalkylation and application in the total synthesis of Neodysidenyn (2 publications).
1/ Valence Tautomerism in Titanium Enolates: Direct Radical Haloalkylation and Application in the Total Synthesis of Neodysidenin. S. Beaumont, E. A. Ilardi, L. R. Monroe, A. Zakarian, J. Am. Chem. Soc., 2010, 132 (5), 1482-1483.
2/ Marine Toxins with Spiroimine Rings: Recent Progress in Synthesis. A. Zakarian, S. Beaumont, E. A. Ilardi, Eur. J. Org. Chem., 2010, (30), 5743-5765 (Review).
Institut de Chimie des Substances Naturelles CNRS
- Ph.D. in organic synthesis under the supervision of Dr R. H. Dodd and Ph. Dauban
2005 - 2008
Synthesis of indolobenzazepinones, acting as inhibitors of tubulin polymerization (3 publicataions, 1 patent).
- Palladium-catalyzed cross-coupling reactions, C-H arylation, multicomponent reactions (Ugi, Passerini).
Rhodium-catalyzed amidation of indoles (1 publication).
- Functionalization of indoles, nitrenes reactivity.
1/ New C5-Alkylated Indolobenzazepinones Acting as Inhibitors of Tubulin Polymerization: Cytotoxic and Antitumor Activities. L. Keller, S. Beaumont, J.-M. Liu, J. Bignon, J. Bakala, P. Dauban, R. H. Dodd, J. Med. Chem., 2008, 51, 3414-3421.
2/ Synthesis of Indolobenzazepinones by Application of an Isocyanide Based Multicomponent Reaction. S. Beaumont, V. Pons, P. Retailleau, P. Dauban, R. H. Dodd, Eur. J. Org. Chem., 2008, 51, 5162-5175.
3/ Catalytic Oxyamination of Indoles. S. Beaumont, V. Pons, P. Retailleau, R. H. Dodd, P. Dauban, Angew. Chem. Int. Ed., 2010, 49, 1634-1637.
4/ Rigid analogues of antimitotic indolobenzazepinones: new insights into tubulin binding via molecular modeling. V. Pons, S. Beaumont, M. E. Tran Huu Dau, B. Iorga, R. H. Dodd , ACS Med. Chem. Lett., 2011, 2 (8), 565-570.
5/ Novel Water-Soluble Indolobenzazepine Molecules Demonstrating Antimitotic, Antivascular, and Antitumor Activities in Vivo. Bakala J., Beaumont S., Bignon J., Dodd R., Liu J., Pons V., WO 2012059568.
