Mes compétences :
Génétique
Cancérologie
Culture cellulaire
Biologie moléculaire
Biologie
Entreprises
CNRS Institut Gustave Roussy
- Étudiante en thèse
2012 - 2016Étude des relations moléculaires et fonctionnelles entre le facteur de transcription MITF et la voie de réparation FANC/BRCA
CNRS Institut Gustave Roussy
- Stagiaire de Recherche
2012 - 2012Stage de recherche de 6 mois
Analyse des relations entre la voie de réparation FANC et le facteur de transcription MITF dans les mélanomes cutanés
Techniques: Culture cellulaire, Western blot, Immunofluoresence, Cytométrie en flux
Harvard University et Beth Israel Deacon'nes Medical Center
- Stagiaire de Recherche
2011 - 2011Understand the heterotypic crosstalk that operates between the epithelial and the stromal compartments within carcinomas, with particular emphasis on how these interactions influence cancer metastasis.
Previous work indicated that certain bone-marrow-derived progenitor cells termed mesenchymal stem cells (MSCs) can home specifically to developing neoplasms where they integrate into the tumor stroma. Within this microenvironment, the tumor-associated MSCs become activated, and initiate de novo secretion of chemokines, cytokines, growth factors, and matrix proteins which act on the cancer cells and promote their growth, motility, invasion, and metastasis. The major current efforts of our group are now directed towards (1) deciphering the nature of the cancer-derived systemic signals that affect the bone marrow, and how such interactions mobilize MSCs and cause their recruitment to the tumor microenvironment; (2) characterizing the nature of the heterotypic interactions that cause the activation of MSCs within the tumor stroma, and (3) elucidating the various mechanisms by which MSCs exert their pro-malignant functions.
Techniques: Cell culture (MSCs, cancer cells), Construction of Vectors, Cell Transformation, PCR and quantitative PCR, Western Blot, Immunofluorescence.
INSERM U658 Caractérisation du tissu osseux par imagerie : techniques et applications
- Stagiaire Recherche
2010 - 2010Etude des cascades biologiques regulant la reparation et la régénration tissulaire et cellulaire.
Atlas de l'Imagerie du Tissu Osseux, C.L. Benhamou and G.Y. Rochefort, Servier, 2010.
Mesenchymal stem cells and acquisition of a bone phenotype: a ion channel overview, Priscilla C. Aveline, J.I. Bourseguin and G.Y. Rochefort, accepté dans Bone Marrow Research (Octobre 2011)
Fondation d'Aligre et Marie Thérèse
- Agent des Services Hospitaliers
2008 - 2009Soins et accompagnement dans les gestes de la vie quotidienne de personnes agées et handicapées.
