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Anne BERNARD

Brisbane

En résumé

Since February 2014, I held the position of senior biostatistician at QFAB Bioinformatics in Brisbane, Australia (see description below) and work closely with hospitals, researchers and external clients to provide expertise in the design and analysis of biological and clinical projects.

I received my Master's degree in applied statistics in 2010 and her PhD in biostatistics and more specifically high dimensional data and genetic data analysis in 2013 at the CNAM of Paris, and at the CE.R.I.E.S. (a private research centre on human skin funded by Chanel) under the direction of Pr. Gilbert Saporta, Chair of Applied Statistic, and Dr. Christiane Guinot. The main issue was the development of sparse methods (dimension reduction and variable selection), suitable for microarray data and analysis of SNPs data. I made several scientific communications in national and international statistical congresses.

Prior starting my PhD she did a MSc internship at the CE.R.I.E.S. in 2010 in the Biometrics and Epidemiology unit, under the responsibility of Christiane Guinot (HDR) to study the effect of sleep deprivation on biophysical skin properties, on mood and cognitive functions.

Specialties: treatment of high dimensional data, genetic data analysis, development of sparse methods (selection of variables and dimension reduction).


Mes compétences :
Logiciel R
SAS
Statistiques
Statistiques appliquées
R

Entreprises

  • QFAB Bioinformatics - Senior Biostatistician

    Brisbane 2014 - maintenant • Provide expertise in the design of clinical studies (including sample size estimation, power calculation and study conduct) and in the analysis and interpretation of study data

    • Development of a biostatistic tools and guidelines on statistical trial designs and methodologies for the Australia and New Zealand Melanoma Trials Group

    • Provide statistical methodology section for study protocol, develop statistical analysis plan,
    perform statistical analysis and drafts statistical report as required

    • Provide statistical consulting to Translational Research Institute (Brisbane, Australia), Princess
    Alexandra Hospital, Radiation Oncology Department of PAH hospital: statistical analysis for
    evaluation of accuracy of tools or systems used in RO, comparison of radiotherapy techniques
    such as three-dimensional conformal radiotherapy (3D-CRT), intensity modulated radiotherapy
    (IMRT), and volumetric modulated arc therapy (VMAT), co-author of 8 papers submitted
    in 2015

    • Analysis of high-throughput omics datasets: supervised and unsupervised multivariate analysis ((s)PCA, (s)PLS, (s)PLS-DA, (s)MCA, CCA...), analysis of methylation, proteomics, SNPs and gene expression data, survival analysis, R programming

    • Conduct quantitative analysis of biological data in research and customer projects and work
    closely with customers to understand their research projects: Skype or face-to-face meetings
    with clients for each projects and close-out

    •Assist with project management to ensure delivery to partners and clients on time and within
    budget and assist in project proposal development

    • Contribute to designing, organising and managing training programs for researchers and clinicians

    • Report research results to the scientific community via reports, posters, papers and presentations

    • Supervision of other staff, interns and/or students in relevant projects (co-supervision of a PhD student in biostatistics on Time Course Omics data)

  • CERIES et CNAM de Paris - PhD Student in biostatistics

    2010 - 2013 Development of statistical methods for high-dimensional genomic data analysis (microarray) to find links between skin ageing and genes:
    • Analysis of SNPs data (Single Nucleotide Polymorphisms), SNPs coding , quality control
    • Development of new sparse methods for dimensionality reduction and variable selection
    (Sparse Principal Component Analysis for multiblocks data, Sparse Multiple Correspondence
    Analysis)
    • Use of supervised sparse methods such as sparse Partial Least Squares (sPLS), Elastic-Net, Lasso, group Lasso
    • Analysis of SNPs-SNPs interactions: class association rules methods, logic regression
    • Oral communications in national and international congresses
    • Publications in international scientific journals and development of R packages
    • Programming and implementation of R packages
    • Participation to the Scientific Advisory Board of the CE.R.I.E.S. each year

  • CERIES, Chanel - MSc Internship in biostatistics

    2010 - 2010 Study of chronic sleep deprivation effects on biophysical skin properties, on mood and cognitive functions of young healthy women
    • Utilisation of statistical methods such as ANOVA, structural equation modeling, PLS Path modelling and PLS regression
    • Co-author of the publication of the study
    • Setting up a study on the perception of facial digital images in 2D and 3D stereoscopy, creation of input masks and control programs, input data validation, analysis and interpretation of the statistical results of the study and writing of the study report
    • Participation to the Scientific Advisory Board of the CE.R.I.E.S., achievement of visuals supports and summaries of studies

  • INRA - MSc Internship in statistics

    Paris 2009 - 2009 Spatio-temporal analysis of the spread of the Esca (wood disease) by aggregation methods of
    spatial analysis (quadrat method, the nearest neighbour method)

    Field analysis, detection of sick vines and statistical analysis of the data

Formations

  • Université Bordeaux

    Bordeaux 2005 - 2010 mathématiques appliquées (statistiques)

    mathématiques appliquées (statistiques) - Licence de mathématiques fondamentales, puis Master de statistiques

Réseau

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